ROR1 Antigen

ROR1, the Receptor tyrosine kinase-like orphan receptor 1, is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. RORs are classified as pseudokinases lacking detectable catalytic activity. They are highly homologous in humans and mice. ROR1 and ROR2 are composed of a distinguished extracellular region with one immunoglobulin domain, one frizzled domain, and one kringle domain, followed by a transmembrane region and an intracellular region that contains a tyrosine kinase domain. ROR1 stands out for its selective and high expression in numerous blood and solid malignancies compared with a minimal expression in healthy adult tissues. Current understanding attributes a survival role for ROR1 in cancer cells; however, its oncogenic function is cancer-type-specific and involves various signaling pathways.


 Clone: 2A2  Isotype: IgG1 Mouse

Epitope mapping studies showed that the 2A2 clone recognized N-terminal epitopes in the extracellular region of ROR1.
 

Choose a ROR1 Model

No Data Available
No Data Available

Las especificaciones anteriores no son representativas de todos los reactivos, sino solo del número de artículo/pieza al que se hace referencia en esta tabla de especificaciones de la línea de productos. Consulte la página de detalles de un producto para ver todas las especificaciones del producto de ese reactivo concreto.


Documentos técnicos