Dry Stimulation Mixes for Immune Functional Assays. Lipopolysaccharide (LPS), a constituent of the membrane of gram-negative bacteria, represents a pathogen-associated molecular pattern (PAMP). Brefeldin A blocks Golgi-apparatus-mediated secretion. A mix of these 2 compounds strongly activates cells of the innate immune system expressing LPS-recognizing surface receptors such as monocytes and traps newly synthesized biomolecules (e.g., cytokines) inside the cell, indicating the capacity to respond to microbial pathogens.
The DURActive stimulation kits contain optimally dosed physiologically active compounds provided as unitized single tests in 12x75mm tube format.
|Specificity||Lipopolysaccharide / Brefeldin A|
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