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¿Qué es la inmunoterapia celular?

La inmunoterapia celular modifica las células inmunes de una persona (p. ej., mediante ingeniería genética o modulación del perfil de expresión de las proteínas) antes de reintroducirlas en el cuerpo con fines terapéuticos. Por ejemplo, se pueden aislar linfocitos T directamente de un paciente y luego modificarlos en un laboratorio de investigación para expresar receptores dirigidos a los antígenos específicos de las células cancerosas. Luego, se permite a estos linfocitos T modificados que se multipliquen en incubadoras, tras lo cual se vuelven a introducir en gran número en el paciente para buscar células cancerosas para su eliminación por medios inmunológicos.²

Referencia:
1. Z. Tao, et al., "Cellular immunotherapy of cancer: an overview and future directions," Immunotherapy 9(7):589-606, 2017.

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