B Cell Malignancies

B-ALL arises from genetic abnormalities that block lymphoid differentiation, driving aberrant cell proliferation and survival by evading apoptosis.

All CLLs are derived from mature, antigen-experienced B cells that may proceed down one of two cellular pathways after antigen exposure, giving rise to two distinct disease subsets.

Mantle cell lymphoma (MCL) is an aggressive and rare type of non-Hodgkin lymphoma (NHL) that develops from malignant B lymphocytes originating in the outer edge of the lymph node follicle, known as the mantle zone.

Plasma cell neoplasms are diseases resulting from the excessive clonal proliferation of plasma cells – or myeloma cells – in the bones and soft tissues of the body.

The genetic hallmark of FL is the chromosomal translocation t(14;18), which is found in about 85% of patients.

B cell lymphoma refers to a group of cancers that develop from the abnormal production of B cells, also known as B lymphocytes.